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Real-world effectiveness of LAIV-4 was higher against influenza A(H3N2) than previously reported, possibly reflecting increased effects of LAIV-4 due to low pre-existing influenza immunity in the children following the COVID-19 pandemic.
Live attenuated influenza vaccine (LAIV) might increase the risk of wheezing in persons with asthma or children younger than 5 years with a history of recurrent wheezing. Objective: To describe the use and assess the safety of LAIV in persons with asthma in the Vaccine Safety Datalink population. Methods:
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The LAIV contains weakened viruses and is a given by intranasal spray. LAIV can be used for people 2-49 years of age. LAIV is a quadrivalent vaccine, which is designed to protect against four different flu viruses, including two influenza A viruses and two influenza B viruses.
Abstract. The USA has a long-standing paediatric influenza vaccination programme, including use of live attenuated influenza vaccine (LAIV). Following US evidence of apparent lack of vaccine effectiveness (VE) of LAIV in 2015/2016, particularly against A (H1N1)pdm09, the USA suspended the use of LAIV in the 2016/2017 season.
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